Directions to Karl Strauss Brewing Company - Downtown San Diego Search | Advanced Search | New Members | Coupons and Discounts | All Categories Other >> Brewery Member Karl Strauss Brewing Company - Downtown San Diego 1157 Columbia StreetSan Diego, CA 92101 | map 619-234-2739 Visit Site Get directions to: Karl Strauss Brewing Company - Downtown San Diego, 1157 Columbia Street, San Diego CA Get directions from: Click to Print This Page